Why using Bone Marrow Concentrate preparation ?
Bone marrow is a liquid tissue rich in a heterogeneous population of mature cells and multipotent stem cells.Among them, the mesenchymal stromal cells (MSC) are the musculoskeletal tissue precursor cells. RegenKit® Extracell® BMC kits are specifically designed for the effective processing of bone marrow aspirate (BMA).
The mononuclear cell (MNC) fraction contains the MSC. In vitro, these cells give rise to fibroblast colony-forming units (CFU-F) capable of undergoing osteogenesis, chondrogenesis and adipogenesis when cultured in their respective specific induction medium1.
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Clinical evidence
BMC are used alone3, 8, or in combination with bone grafts or synthetic osteoconductive scaffolds4-8.
BMC can also be combined with platelet-rich plasma (RegenPRP) and autologous thrombin serum (ATS) prepared with RegenKit® Surgery to obtain a gel.
Results
BMC prepared with RegenKit® Extracell® from a small volume of bone marrow aspirate (max 40 ml) have been used successfully for complex bone healing problems such as:
- Nonunion (Pseudarthrosis)2-3
- Osteonecrosis (Avascular necrosis of the hip)4-5
- Bone cysts and large bone loss (after bone tumor removal or trauma)6-9
Conclusion
Complete healing was obtained for around 80% of the lesions1-8
Bibliography
- Barry, F., A Report on The Phenotypic Characterization of Mesenchymal Stem Cells isolated from Human Bone Marrow Using the RegenTHT, A-CP and Regen BCT Blood Separation Systems. 2015, The Regenerative Medicine Institute (REMEDI), National University of Ireland Galway.
- Scaglione, M., et al., Long bone nonunions treated with autologous concentrated bone marrow-derived cells combined with dried bone allograft. Musculoskelet Surg, 2014. 98(2): p. 101-6.
- Toro, G., et al., Surgical treatment of neglected hip fracture in children with cerebral palsy: case report and review of the literature. Clin Cases Miner Bone Metab, 2017. 14(3): p. 317-23.
- Civinini, R., et al., The use of an injectable calcium sulphate/calcium phosphate bioceramic in the treatment of osteonecrosis of the femoral head. Int Orthop, 2012. 36(8): p. 1583-8.
- De Biase, P., et al., Regenerative Medicine In The Treatment Of Osteonecrosis Of The Hip: A Comparative Clinical Study On The Use Of Autologous Cell Concentrates In The Presence Or Absence Of BMP, in EFORT congress. 2016: Geneva. p. #1343 – Free Papers.
- De Biase, P., et al., Scaffolds combined with stem cells and growth factors in healing of pseudotumoral lesions of bone. Int J Immunopathol Pharmacol, 2011. 24(1 Suppl 2): p. 11-5
- De Biase, P., et al., The “in-Vivo Cell Factory” Concept As An Alternative To Traditional Tissue Engineering In The Repair Of Large Cavitary Bone Defects., in EFORT congress. 2016: Geneva. p. #1344 – Free Papers
- De Biase, P., et al., Scaffolds combined with stem cells and growth factors in healing of pseudotumoral lesions of bone. Int J Immunopathol Pharmacol, 2011. 24(1 Suppl 2): p. 11-5.
- Andreani, L., et al., Bone Marrow Concentrate in the Treatment of Aneurysmal Bone Cysts: A Case Series Study. Stem Cells Int, 2020. 2020: 8898145.
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