STRESS URINARY INCONTINENCE

Stress urinary incontinence (SUI) is usually the result of the weakening of, or damage to, the muscles used to prevent urination, such as the pelvic floor muscles and the urethral sphincter. Its prevalence is estimated to 40% of adult women.

OBJECTIVE

Evaluate the effectiveness of injection of RegenPRP™ as a treatment for women suffering from SUI.

PROTOCOL

Prospective intervention study on 20 women suffering from SUI that received 3 treatments with RegenPRP™ at monthly intervals. Five ml of RegenPRP™ were injected into the anterior vaginal mucosa around the patient’s mid-urethra: Two ml underneath mid-urethra and 1.5 mL for each side of urethra.

RESULTS

RegenPRP™ was effective in relieving SUI symptoms at both 1 month and 6 months post-treatment:

• SUI grade, evaluated with the International Consultation on Incontinence Questionnaire- Short Form (ICIQ-SF) score, illustrated a shift in the distribution of disease severity to milder disease after PRP treatment (See figure 1). The treatment was considered effective for 60% (12/20) of the patients.

• Treatment efficacy as assessed by ICIQ-SF, Urogenital Distress Inventory (UDI-6), Incontinence Impact Questionnaire (IIQ-7) and Overactive Bladder Symptom Scores (OABSS) showed a significant improvement in incontinence. All these scores revealed significant and lasting effectiveness. Younger women (<40 years old) tended to have better treatment outcomes (p = 0.07).

The urodynamic studies performed on 8 women showed that residual urine and bladder volume at first sensation to void increased significantly 6 months after injection of RegenPRP™.