RegenExtracell BMC®
The Flexible & Reproducible Bone Marrow Concentrate SystemWhat is RegenExtracell BMC ?
BONE MARROW CONCENTRATE (BMC) IS AN AUTOLOGOUS CELL CONCENTRATE FROM BONE MARROW ASPIRATE.
Bone marrow is a liquid tissue rich in a heterogeneous population of mature cells and multipotent stem cells. Among them, the mesenchymal stromal cells (MSC) are the musculoskeletal tissue precursor cells.
RegenBMC tubes contain a chemically inert separating gel with a specific density that allows the physical separation of plasma and mononuclear cell (MNC) fractions from the other cellular elements of the bone marrow aspirate. This allows intraoperative processing of bone marrow aspirate to produce a bone marrow cell concentrate that is reimplanted during the same surgical procedure without the need for cell selection and expansion in the laboratory (‘one-step therapy’). 1
More than 80 % of the MSCs are recovered in the resulting cell concentrate. In vitro, these cells form colony-forming fibroblast units (CFU-F), which are capable of undergoing osteogenesis, chondrogenesis and adipogenesis when cultured in their respective specific induction medium. By transferring the regenerative potential of the bone marrow to the site of the lesion, BMC represents an interesting therapeutic option for the treatment of damaged musculoskeletal tissues, e.g., difficult to heal bone lesions.
Bibliography
1 Holton J, Imam MA, Snow M. Bone Marrow Aspirate in the Treatment of Chondral Injuries. Frontiers in surgery 2016;3:33.
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